Cutaneous Malignancy

2.2.1 Name the major skin carcinogens that can initiate precancerous growth.

2.2.2 What conditions predispose to cutaneous malignancy (xeroderma pigmentosa, basal cell nevus syndrome, actinic keratosis, nevus sebaceous to name a few!)? Tell us what patients are particularly at risk for developing cutaneous malignancies.

2.2.3 Discuss tumors that mimic SCCA (keratoacanthoma, pseudoepitheliomatous hyperplasia, and desmoplastic melanoma).

2.2.4 What cells do BCCA arise from? SCCA?

2.2.5 Copy and prepare to discuss the Fitzpatrick classification of skin types.

2.2.6 What are Bowen’s disease? Marjolin’s ulcer? Verrucous carcinoma?

2.2.7 List the different types of BCCA; microscopic and clinical distinctions? 

http://portal.entnet.org/images/COCLIA/2011-2012%20updates/COCLIA%20Media/Cutaneous%20Malignancy/Cutaneous-Malignancy-Q7-080312_056.jpg

2.2.8 List the prognostic factors for SCCA recurrence and metastasis.

Immerman SC, Scanlon EF, Christ M, Knox KL. Recurrent squamous cell carcinoma of the skin. Cancer. 1983 Apr 15;51(8):1537-40. PMID:6825059

Lawrence N, Cottel WI. Squamous cell carcinoma of skin with perineural invasion. J Am Acad Dermatol. 1994 Jul;31(1):30-3. PMID:8021368

2.2.9 What are the treatment modalities for BCCA and SCCA? Discuss the importance of margins in surgery for each cell type and why.

2.2.10 What is Mohs surgery? Who should get it?

Cottel WI, Proper S. Mohs' surgery, fresh-tissue technique. Our technique with a review. J Dermatol Surg Oncol. 1982 Jul;8(7):576-87. PMID:6181110

2.2.11 What are retinoids and what role do they have in the treatment of skin CA?